SURFACE THERMODYNAMICS EXPERIMENTAL PROCEDURE FOR THE EFFICACY OF PARTICLES INTERACTION

Abstract

Surface thermodynamics study is the application of the mind to an investigative search for the nature and rate of heat transfer on the surface of any particle-particle interaction. This paper presents the theory and a designed practical manual for the demonstration of the Combined Hamaker Coefficient-a thermodynamic method for the determination of the nature and effectiveness of the interactions between any two or more interacting particles. In essence, the Hamaker theory established that “if two particles are embedded in a fluid and the London-van der Waal’s force between the particles and the fluid is greater than between the particles themselves, it might be thought that the resultant action will be repulsion rather than an attraction”. In a case study of; a healthy blood lymphocyteand a HIV particles in a serum fluid containing herbal antiviral drug particle, the Hamaker theory that is fundamentally based on the Van der Waal’s theory for the potential surface heat energy of attraction and repulsion can be demonstrated. Furthermore, the interfacial work done by particles can be investigated during their combined interactionin an in-vivo experiment. The data obtained can prove that the Combined Hamaker Coefficient, when negative is responsible for particle-particle repulsion and positive for particle-particle attraction. Negative absolute combined Hamaker coefficient (A132abs.), implies repulsion of say, a virus particle2 in lymphocyte, by drug particle3 in an intervening liquid medium like serum, and as such, particle1 which is considered to be a virus-free lymphocyte, is coated against a possible contact with particle2. Hence, the overall change of the chemical energy potential of all particle matter, to heat energy, is revealed to be a concurrent area of a Surface Thermodynamics science and engineering study that employs mathematical concepts and appropriate iteration software in a current design and formulation of drugs for the management of viral and other natural diseases.